• Undefined

TOPICS

Meeting Unmet Medical Needs

• Anti-infectives

• Anticancer therapeutics

• Neuroactive drugs

Advancing strategies in drug discovery and development

• Computational medicinal chemistry

• Discovery of small molecule probes

• Epigenetics

• New chemical entities from nature

• Redox active targets and compounds


CONFIRMED PLENARY SPEAKERS

Prof. Dr. Nenad Ban   |   ETH, Switzerland
Beyond the Prokaryotic Ribosome: Structural and Functional Insights Into Eukaryotic and Mitochondrial Ribosomes
We are investigating bacterial and eukaryotic ribosomes and their functional complexes to obtain insights into the process of protein synthesis. Eukaryotic ribosomes are much more complex than their bacterial counterparts    ... more

Prof. Dr. Gerhard Klebe   |   University of Marburg, Germany
What Thermodynamics Can Help to Understand Protein-Ligand Binding in Medicinal Chemistry
Small-molecule drug discovery involves the optimization of various physicochemical properties of a ligand, particularly the binding affinity for its target receptor(s). In recent years, there has been growing interest in using thermodynamic profiling of ligand–receptor interactions in order to   ... more

Prof. Dr. Paul Brennan   |   University of Oxford, UK
Chemical Probes in Target Discovery
Epigenetics is the study of heritable changes in phenotype that are not encoded in an organism’s DNA. Epigenetic effects due to persistent changes in gene transcription have been linked to chemical modification of DNA and the proteins that package and regulate DNA in the nucleus, histones. One of the major post-translational modifications of histones   ... more

Prof. Dr. Margot Ernst   |   Medical University Vienna, Austria
GABAA Receptor Subtypes: A Structure Guided Path to Selective Compounds
Atomic resolution structures of cys-loop receptors, including one of a GABAA receptor subtype, allow amazing insights into the structural features of these pentameric ligand-gated ion channels. Here we present a comprehensive analysis of more than thirty cys-loop receptor structures   ... more

Prof. Dr. Ivo Piantanida   |   Ruđer Bošković Institute, Croatia
Design of Small Molecular Probes for Proteins and DNA / RNA
Small molecules targeting DNA, RNA and/or proteins have attracted significant scientific interest not only because of their biomedicinal applications, but also due to widespread use of spectrophotometric markers in the related scientific research.   ... more

Prof. Dr. Martin Krátký   |   Charles University, The Czech Republic
Oligotuftsin-based Carriers for Novel Antimycobacterial Active Agents and Their Conjugates
The global tuberculosis epidemic and increasing emergence of drug-resistant Mycobacterium tuberculosis (Mtb.) strains as well as non-tuberculous mycobacteria (NTM) call for intensive research on novel therapeutic interventions.   ... more

Prof. Dr. Grigoris Zoidis   |   National and Kapodistrian University of Athens, Greece
Metal Chelating Agents Against Viruses and Parasites
Influenza viruses cause considerable morbidity and mortality, whether in the context of annual epidemics, sporadic pandemics, or outbreaks of avian influenza virus. For hepatitis C virus (HCV), an estimated 170 million people are chronically infected worldwide.   ... more

Prof. Dr. János Wölfling   |   University of Szeged, Hungary
Old Scaffolds in New Role: Steroids as Antiproliferative Agents
One of the main trends in medicinal chemistry is the structural modification of biologically active natural products with the aim of obtaining drug-like molecules with selective biological action. Steroids can be found widespread in nature; their function in plants, in human and in animal body is mostly well-known.   ... more

Prof. Dr. Girolamo Cirrincione   |   University of Palermo, Italy
Marine Environment Inspires Kinases Inhibitors
Marine organisms constitute a very unique source of bioactive molecules belonging to a great variety of different chemical structural classes. Among marine derived bioactive molecules, over 70 novel compounds showed significant inhibitory activity against kinases,   ... more

Prof. Dr. Jadwiga Turlo   |   Medical University of Warsaw, Poland
Polysaccharides as Biological Response Modifiers: Structure-Activity Relationship
Polysaccharides are among the best known and most potent macromolecules with antitumor and immunomodulatory properties. With respect to the mechanism of the pharmacological activity, they are classified as biological response modifiers (BRMs).   ... more


Prof. Dr. Stanislav Gobec   |   University of Ljubljana, Slovenia
New Hits and Leads for Neurodegenerative Disorders
Alzheimer’s disease (AD) is characterized by severe cholinergic deficit, which results in progressive and chronic deterioration of memory and cognitive functions. Together with acetylcholinesterase, butyrylcholinesterase (BChE) contributes to the termination of cholinergic neurotransmission.   ... more

 

CONFIRMED KEYNOTE SPEAKERS


Dr. Hannes Mikula   |   Technical University Vienna, Austria
Pretargeted Prodrug Activation Through Bioorthogonal Elimination
The field of bioorthogonal chemistry has been growing steadily and fascinating scientists worldwide for more than 15 years with the challenge of engineering chemical transformations that can proceed within the molecularly complex environment of living systems.   ... more

Prof. Dr. Vesna Eraković Haber   |   Fidelta Ltd., Croatia
Patient Derived Testing Systems – Reaching Beyond Targed Based Drug Discovery
Great advances in modern science have provided a clear rational and powerful tools for target based drug discovery. Combinatorial chemistry and parallel synthetic methods have increased significantly number of molecules synthetized by chemists.   ... more

Dr. Robert Vianello   |   Ruđer Bošković Institute, Croatia
Computational Insight into the Catalytic Activity of Monoamine Oxidase Enzyme for Targeting Neurological Diseases
Monoamine oxidase (MAO) is an FAD-dependent flavoenzyme responsible for metabolizing a very broad range of biogenic amines including many neurotransmitters in the brain, such as dopamine and serotonin, whose imbalance is extensively linked with the development and progression of many neurological disorders including Parkinson and Alzheimer disease   ... more

Dr. Marta Kučerová-Chlupáčová   |   Charles University, The Czech Republic
Antimicrobial Potential of 1,2,4-Oxadiazoles and Their Synthesis
1,2,4–Oxadiazole ring represents an emerging scaffold in medicinal chemistry used as heterocyclic bioisoster of amide or ester in the synthesis of peptide building blocks and in the formation of dipeptidomimetics. In comparison with amide or ester group,   ... more

Dr. Radim Nencka   |   Czech Academy of Sciences, The Czech Republic
Rational Design of PI4KB Inhibitors as Potential Broad-spectrum Antiviral Agents
Phospatidylinositol 4-kinases (PI4Ks) are enzymes responsible for phosphorylation of phosphatidylinositols, common constituents of the plasmatic membranes inside of cells. Numerous positive-sense single stranded RNA (+ssRNA) viruses hijack phosphatidylinositol 4-kinase IIIβ (PI4KB),   ... more

Dr. Nektarios Aligiannis   |   National and Kapodistrian University of Athens, Greece
Can Multivariate Statistics Aid to the Reveal of Bioactive Compounds? An NMR and HPTLC Approach
Greece has an exceptionally rich flora which forms, geographically and historically, a link between the plant-life of Europe and that of Asia. It is characterized by high biodiversity, consisting of 6300 species of which 950 are endemic   ... more

Prof. Vasiliki Sarli   |   Aristotle University of Thessaloniki, Greece
New Drug Conjugates Based on Azasteroids or Peptides for Targeted Drug Delivery in Cancer Therapy
Targeted drug delivery systems (TDDS) offer an attractive strategy to minimize systemic toxicity and achieve the best therapeutic effect with a lower dose. Peptides (e.g. Arg-Gly-Asp (RGD) peptides, poly-Arg peptides, octreotide, bombesin) and steroids   ... more

Prof. Marco Macchia   |   University of Pisa, Italy
Endocannabinoid System Modulation: Therapeutic Implications and Future Perspectives
The endocannabinoid system (ECS) consists of two G protein-coupled receptors (CB1R and CB2R), their endogenous ligands, anandamide (AEA) and 2-arachidonoylglycerol (2-AG), and the enzymes involved in the biosynthesis and degradation of endocannabinoids, such as fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).   ... more

Prof. Dr. Gianluca Sbardella   |   University of Salerno, Italy
A "Library-on-library" Screening Approach to Identify Small-molecule Ligands of Methyl-lysine Reader Proteins
The discovery of inhibitors of methyl- and acetyl-binding domains has provided evidence for the “druggability” of epigenetic effector molecules. Using a library of biotin-tagged analogs we screened a protein domain microarray of methyl-lysine   ... more

Dr. Krzysztof Kamiński   |   Jagiellonian University, Poland
Hybrid Compounds in the Search for the New Highly Effective Anticonvulsants
The multifunctional ligands approach is one of the modern strategies in drug discovery especially in relation to diseases with complex pathomechanism, such as Alzheimer’s disease, cancer, or epilepsy. This strategy assumes that a single chemical entity is capable of modulating biological targets   ... more

Dr. Maciej Dawidowski   |   Medical University of Warsaw, Poland
Disrupting the PEX14-PEX5 Interaction by Small Molecules Provides a Novel Strategy for Treatment of Trypanosoma Infections
Trypanosoma parasites couple glycolytic and peroxisomal function in a unique organelle, called the glycosome. Glycosomes lack genetic information, therefore the enzymes that are active in the lumen of the organelle need to be translocated post-translationally.   ... more

Dr. Magdaléna Májeková   |   Slovak Academy of Sciences, Slovakia
Ligand-based Drug Design of Novel Aldose Reductase Inhibitors from Databases of Indole-1-Acetic Acids
Aldose reductase (ALR2) is a frequent therapeutic target in searching for efficient treatment of long-term diabetic complications and other chronic diseases. Compounds with indole-1-acetic acid moiety are known as promising leads for design of aldose reductase inhibitors (ARIs).   ... more

Dr. Pavol Jakubec   |   Slovak University of Technology, Slovakia, and Harward University, USA
A Platform for the Discovery of New Macrolide Antibiotics
Chemically modifying structurally complex fermentation products, a process referred to as semisynthesis, has been a primary tool for the discovery and manufacture of antibiotics for the treatment of human infectious diseases. Many of the medicines obtained in this way are no longer efficacious   ... more

Dr. Matej Sova   |   University of Ljubljana, Slovenia
Design and Synthesis of Novel Modulators of Toll-like Receptors and Inhibitors of Indoleamine 2,3-Dioxygenase (IDO1)
Two targets, namely Toll-like receptors (TLRs) and indoleamine 2,3-dioxygenase (IDO), have been of high interest for the design of small-molecule agents for autoimmune, inflammatory or infectious diseases and cancer. TLRs as the key component of human innate immune system   ... more

Dr. Nace Zidar   |   University of Ljubljana, Slovenia
Discovery of N-phenylpyrrolamides as ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
Bacterial topoisomerases are enzymes that catalyse changes in DNA topology and are clinically validated targets of antibacterial drugs. DNA gyrase and topoisomerase IV belong to type IIA topoisomerases and display high structural and functional similarities.   ... more

FINAL PROGRAMME

SUNDAY, JUNE 25
14:00-17:00 Registration
17:00-17:30 Opening of the Meeting
A WAY FORWARD TO NEW ANTI-INFECTIVES
Moderator: Gabriele Costantino (Italy)
17:30-18:15 PL-1 Nenad Ban (ETH Zürich, CH)
Beyond the Prokaryotic Ribosome: Structural and Functional Insights Into Eukaryotic and Mitochondrial Ribosomes
18:15-18:45 KL-1 Pavol Jakubec (Slovak University of Technology, SK; Harward University, USA)
A Platform for the Discovery of New Macrolide Antibiotics
18:45-19:25 PL-2 Martin Krátký (Charles University, CZ)
Oligotuftsin-based Carriers for Novel Antimycobacterial Active Agents and Their Conjugates
19:30 Welcome party
MONDAY, JUNE 26
RATIONAL APPROACH TO THE DESIGN OF NOVEL DRUGS
Moderator: Margot Ernst (Austria)
9:00-9:45 PL-3 Gerhard Klebe (University of Marburg, DE)
What Thermodynamics Can Help to Understand Protein-Ligand Binding in Medicinal Chemistry
9:45-10:15 KL-2 Nace Zidar (University of Ljubljana, SI)
Discovery of N-phenylpyrrolamides as ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
10:15-10:45 Coffee break
ANTI-INFECTIVE CASE STUDIES
Moderator: Marko Anderluh (Slovenia)
10:45-11:25 PL-4 Grigoris Zoidis (National and Kapodistrian University of Athens, GR)
Metal Chelating Agents Against Viruses and Parasites
11:25-11:55 KL-3 Marta Kučerová-Chlupáčová (Charles University, CZ)
Antimicrobial Potential of 1,2,4-Oxadiazoles and Their Synthesis
11:55-12:25 KL-4 Radim Nencka (Czech Academy of Sciences, CZ)
Rational Design of PI4KB Inhibitors as Potential Broad-spectrum Antiviral Agents
12:25-15:00 Lunch   –   POSTER SESSION I
FILLING THE GAP IN THE DISCOVERY OF NEW ANTI-CANCER DRUGS
Moderator: Ivo Piantanida (Croatia)
15:00-15:40 PL-5 Girolamo Cirrincione (University of Palermo, IT)
Marine Environment Inspires Kinases Inhibitors
15:40-16:10 KL-5 Matej Sova (University of Ljubljana, SI)
Design and Synthesis of Novel Modulators of Toll-like Receptors and Inhibitors of Indoleamine 2,3-Dioxygenase (IDO1)
16:10-16:30 Coffee break
16:30-17:10 PL-6 János Wölfling (University of Szeged, HU)
Old Scaffolds in New Role: Steroids as Antiproliferative Agents
17:10-17:40 KL-6 Vasiliki Sarli (Aristotle University of Thessaloniki, GR)
New Drug Conjugates Based on Azasteroids or Peptides for Targeted Drug Delivery in Cancer Therapy
18:30 Trip to Dubrovnik
TUESDAY, JUNE 27
LOOKING AT THE EPIGENETIC LEVEL
Moderator: János Wölfling (Hungary)
9:00-9:45 PL-7 Paul Brennan (University of Oxford, UK)
Chemical Probes in Target Discovery
9:45-10:15 KL-7 Gianluca Sbardella (University of Salerno, IT)
A "Library-on-Library" Screening Approach to Identify Small-Molecule Ligands of Methyl-Lysine Reader Proteins
10:15-10:35 Coffee break
IN SEARCH FOR NOVEL BIOLOGICALLY ACTIVE MOLECULES
Moderator: Jadwiga Turlo (Poland)
10:35-11:15 PL-8 Margot Ernst (Medical University Vienna, AT)
GABAA Receptor Subtypes:  A Structure Guided Path to Selective Compounds
11:15-11:45 KL-8 Maciej Dawidowski (Medical University of Warsaw, PL)
Disrupting the PEX14-PEX5 Interaction by Small Molecules Provides a Novel Strategy for Treatment of Trypanosoma Infections
11:45-12:15 KL-9 Krzysztof Kamiński (Jagiellonian University, PL)
Hybrid Compounds in the Search for the New Highly Effective Anticonvulsants
12:15-12:45 KL-10 Nektarios Aligiannis (National and Kapodistrian University of Athens, GR)
Can Multivariate Statistics Aid to the Reveal of Bioactive Compounds? An NMR and HPTLC Approach
12:45-14:00 Lunch
TARGETING NEURODEGENERATIVE DISORDERS
Moderator: Vesna Eraković Haber (Croatia)
14:00-14:40 PL-9 Stanislav Gobec (University of Ljubljana, SI)
New Hits and Leads for Neurodegenerative Disorders
14:40-15:10 KL-11 Marco Macchia (University of Pisa, IT)
Endocannabinoid System Modulation: Therapeutic Implications and Future Perspectives
15:10-15:40 KL-12 Robert Vianello (Ruđer Bošković Institute, HR)
Computational Insight into the Catalytic Activity of Monoamine Oxidase Enzyme for Targeting Neurological Diseases
15:40-17:00 Coffee break   –   POSTER SESSION II
ORAL PRESENTATIONS – section I
Moderator: Magdaléna Májeková (Slovak Republic)
17:00-17:15 OP-1 Manabu Kawada (Institute of Microbial Chemistry - BIKAKEN, JP)
Anti-Helicobacter Pylori Activity of a Novel Derivative of Intervenolin
17:15-17:30 OP-2 Nela Malatesti (University of Rijeka, HR)
In vitro Photodynamic Activity of a New Tri-Cationic Amphiphilic Porphyrin Against Herpes Simplex Virus 1, Bacteria And Cancer Cells
17:30-17:45 OP-3 Giannamaria Annunziato (University of Parma, IT)
Discovery of New, Potential Anti-Infective Compounds Based on Carbonic Anhydrase Inhibitors by Rational Target-Focus Repurposing Approach
17:45-18:00 OP-4 Michaela Barančoková (University of Ljubljana, SI)
Discovery of Novel Gyrase B Inhibitors and Gyrase B/Topoisomerase IV (ParE) Dual Inhibitors with In Vitro Antibacterial Activity
18:00-18:15 OP-5 Tommaso Felicetti (University of Perugia, IT)
Fighting Antimicrobial Resistance by Breaking Resistance Mechanisms
18:15-18:30 OP-6 Dmitry Tsvelikhovsky (The Hebrew University of Jerusalem, IL)
α-Enaminones: New Building Blocks for Direct Synthesis of Biologically Active Alkaloids
18:30-18:45 OP-7 Marcin J. Cieślak (Polish Academy of Sciences, PL)
Novel Benzo[b]furan Derivatives - Biological Activity and Protein Target Identification in Leukemic Cells
18:45-19:00 OP-8 Moran Shubely (Bar-Ilan University, IL)
Development of Novel Drug Candidate Against Prostate Cancer
ORAL PRESENTATIONS – section II
Moderator: Jarmila Vinšová (Czech Republic)
17:00-17:15 OP-9 Rafał Kurczab (Polish Academy of Sciences, PL)
Evaluation of Halogen Bonding Hot Spots by Virtual Screening of Commercial Databases - a Case Study of 5-HT7R
17:15-17:30 OP-10 Jaroslaw Polanski (University of Silesia, PL)
Big Data: Avogadro Stoichiometry Explains Hyperbolic Ligand Efficiency Trend
17:30-17:45 OP-11 Vassilios Myrianthopoulos (University of Athens, GR)
From Public Domain Compound Collections to Cell-Active Epigenetic Modulators. The Case of the NCI Repository
17:45-18:00 OP-12 Thavendran Govender (University of KwaZulu Natal, ZA)
Mass Spectrometric Imaging as a Preclinical Tool for Medicinal Chemists
18:00-18:15 OP-13 David Chan Bodin Siebert (Technical University Vienna, AT)
Pyrazoloquinolinones, Revisited GABAA Receptor Tool Compounds
18:15-18:30 OP-14 Svetlana Maklakova (Lomonosov Moscow State University, RU)
Synthesis of Tissue-Specific Conjugates for Targeted Drug Delivery Into Hepatic Cells
18:30-18:45 OP-15 Rosana Leiva (Universitat de Barcelona, ES)
Novel Polycyclic N-acylpyrrolidines as 11β-HSD1 Inhibitors
18:45-19:00 OP-16 Maria Majellaro (University of Santiago de Compostela, ES)
Enantiospecific Modulation Of A2B Adenosine Receptor
20:00 Gala Dinner
WEDNESDAY, JUNE 28
LIGAND-BASED APPROACH
Moderator: Gianluca Sbardella (Italy)
9:00-9:40 PL-10 Jadwiga Turlo (Medical University of Warsaw, PL)
Polysaccharides as Biological Response Modifiers: Structure-Activity Relationship
9:40-10:10 KL-13 Magdaléna Májeková (Slovak Academy of Sciences, SK)
Ligand-based Drug Design of Novel Aldose Reductase Inhibitors from Databases of Indole-1-Acetic Acids
10:10-10:40 KL-14 Hannes Mikula (Technical University Vienna, AT)
Pretargeted Prodrug Activation Through Bioorthogonal Elimination
10:40-11:00 Coffee break
FROM MOLECULAR PROBES TO CLINICS
Moderator: Hannes Mikula (Austria)
11:00-11:40 PL-11 Ivo Piantanida (Ruđer Bošković Institute, HR)
Design of Small Molecular Probes for Proteins and DNA / RNA
11:40-12:10 KL-15 Vesna Eraković Haber (Fidelta Ltd., HR)
Patient Derived Testing Systems - Reaching Beyond Targed Based Drug Discovery
12:15-12:45 WINNING POSTERS FLASH PRESENTATIONS
12:45-13:00 CLOSING

PROGRAMME

PROGRAMME BOOK


BOOK OF ABSTRACTS

BOOK OF ABSTRACTS

BEST POSTERS AWARDS

Out of almost 200 posters, the Jury appointed by the International Scientific Committee selected following three as the best ones:


P32:   SYNTHESIS OF PHOTOSWITCHABLE INHIBITORS FOR CNS APPLICATIONS
Dominik Dreier, M. Holy, K. Jäntsch, H. H. Sitte and M. D. Mihovilovic


P83:   DESIGN, SYNTHESIS AND IN VITRO EVALUATION OF MODULATORS OF PFKFB3 AUTOREGULATORY DOMAIN
Helena Macut, X. Hu, D. Tarantino, S. Pellegrino and M. L. Gelmi


P145:   OPIOID RECEPTOR ACTIVITY AND ANALGESIC POTENCY OF DPDPE PEPTIDE ANALOGUES CONTAINING A XYLENE BRIDGE
Azzurra Stefanucci, Giorgia Macedonio, Ettore Novellino, Sako Mirzaie, Stefano Pieretti, Paola Minosi, Edina Szúcs, Anna I. Erdei, Ferenc Zador, Sandor Benyhe and Adriano Mollica


The winners were awarded with cerftificate and the gift package from our media partner ChemMedChem, a Wiley-VCH and ChemPubSoc Europe journal specializing in traditional medicinal chemistry and nanomedicine. The short presentations of winning posters were held after that.

Best poster award winners